What supplements do both Valter Longo and David Sinclair recommend?

Both Valter Longo and David Sinclair recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Extra Virgin Olive Oil.

Which protocol is better: Valter Longo or David Sinclair?

Both protocols have unique strengths. Valter Longo's Fasting-Mimicking Protocol focuses on fasting, longevity, research, while David Sinclair's Lifespan Protocol emphasizes genetics, anti-aging, sirtuins. The best choice depends on your personal goals, budget, and lifestyle.

Valter Longo vs David Sinclair

Compare Valter Longo's protocol (Longevity Researcher & USC Professor) with David Sinclair's approach (Harvard Genetics Professor & Aging Researcher). Longo emphasizes fasting and longevity, while Sinclair focuses on genetics and anti aging. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Extra Virgin Olive Oil.

Valter Longo

Longevity Researcher & USC Professor

A research-backed fasting protocol centered on the fasting-mimicking diet (FMD), emphasizing periodic caloric restriction cycles to promote cellular regeneration and reduce biological age.

10 products in protocol

David Sinclair

Harvard Genetics Professor & Aging Researcher

A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

12 products in protocol

Side-by-Side Comparison

Category	Valter Longo	David Sinclair
Title	Longevity Researcher & USC Professor	Harvard Genetics Professor & Aging Researcher
Focus Areas	fastinglongevityresearchdiet	geneticsanti agingsirtuinssupplementsresearch
Total Products	3	5
Shared Products	3 products in common
Protocol	A research-backed fasting protocol centered on the fasting-mimicking diet (FMD), emphasizing periodic caloric restriction cycles to promote cellular regeneration and reduce biological age.	A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

What They Agree On

Both Valter Longo and David Sinclair include these 3 products in their protocols — a signal of strong evidence and broad expert consensus.

Omega-3 Fish Oil (High EPA)

High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.

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Omega-3 Fish Oil (High EPA)

supplements

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Vitamin D3 (5000 IU)

High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.

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Vitamin D3 (5000 IU)

supplements

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Extra Virgin Olive Oil

Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.

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Extra Virgin Olive Oil

foods

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Where They Differ

These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Only in Valter Longo's Protocol

All of Valter Longo's products are shared with David Sinclair.

Only in David Sinclair's Protocol

NAD+ Precursor (NMN/NR)

NAD+ precursor supplement in NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) form. Supports cellular energy production and DNA repair by boosting NAD+ levels, which naturally decline with age. A cornerstone supplement in many longevity-focused protocols.

Green Tea (Matcha)

High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.

Product Comparison

Product	Valter Longo	David Sinclair
Omega-3 Fish Oil (High EPA)	Recommended	Recommended
Vitamin D3 (5000 IU)	Recommended	Recommended
Extra Virgin Olive Oil	Recommended	Recommended
NAD+ Precursor (NMN/NR)	---	Recommended
Green Tea (Matcha)	---	Recommended

Frequently Asked Questions

What is the difference between Valter Longo's and David Sinclair's protocols?

What do Valter Longo and David Sinclair both recommend?

Both experts recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Extra Virgin Olive Oil. These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.

Which protocol is better for beginners?

Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Extra Virgin Olive Oil — then gradually explore the unique elements of each protocol based on your specific health goals and budget.