What supplements do both Peter Attia and David Sinclair recommend?

Both Peter Attia and David Sinclair recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU).

Which protocol is better: Peter Attia or David Sinclair?

Both protocols have unique strengths. Peter Attia's Outlive Protocol focuses on medicine-3.0, exercise, metabolic-health, while David Sinclair's Lifespan Protocol emphasizes genetics, anti-aging, sirtuins. The best choice depends on your personal goals, budget, and lifestyle.

Peter Attia vs David Sinclair

Compare Peter Attia's protocol (Physician & Longevity Researcher) with David Sinclair's approach (Harvard Genetics Professor & Aging Researcher). Attia emphasizes medicine 3.0 and exercise, while Sinclair focuses on genetics and anti aging. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU).

Peter Attia

Physician & Longevity Researcher

A Medicine 3.0 framework focused on the four horsemen of chronic disease, emphasizing zone 2 cardio, strength training, metabolic health, and early biomarker screening.

13 products in protocol

David Sinclair

Harvard Genetics Professor & Aging Researcher

A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

12 products in protocol

Side-by-Side Comparison

Category	Peter Attia	David Sinclair
Title	Physician & Longevity Researcher	Harvard Genetics Professor & Aging Researcher
Focus Areas	medicine 3.0exercisemetabolic healthlongevitycardiovascular	geneticsanti agingsirtuinssupplementsresearch
Total Products	5	5
Shared Products	2 products in common
Protocol	A Medicine 3.0 framework focused on the four horsemen of chronic disease, emphasizing zone 2 cardio, strength training, metabolic health, and early biomarker screening.	A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

What They Agree On

Both Peter Attia and David Sinclair include these 2 products in their protocols — a signal of strong evidence and broad expert consensus.

Omega-3 Fish Oil (High EPA)

High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.

⚗

Omega-3 Fish Oil (High EPA)

supplements

Buy on Amazon→

Vitamin D3 (5000 IU)

High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.

⚗

Vitamin D3 (5000 IU)

supplements

Buy on Amazon→

Where They Differ

These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Only in Peter Attia's Protocol

Magnesium (Threonate/Glycinate)

Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.

Creatine Monohydrate

Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.

Electrolyte Mix

Balanced electrolyte mix containing sodium, potassium, and magnesium to support hydration and cellular function. Essential for maintaining energy levels, muscle function, and cognitive performance, especially during fasting or exercise. Sugar-free formulas are preferred in longevity protocols.

Only in David Sinclair's Protocol

NAD+ Precursor (NMN/NR)

NAD+ precursor supplement in NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) form. Supports cellular energy production and DNA repair by boosting NAD+ levels, which naturally decline with age. A cornerstone supplement in many longevity-focused protocols.

Extra Virgin Olive Oil

Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.

Green Tea (Matcha)

High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.

Product Comparison

Product	Peter Attia	David Sinclair
Omega-3 Fish Oil (High EPA)	Recommended	Recommended
Vitamin D3 (5000 IU)	Recommended	Recommended
Magnesium (Threonate/Glycinate)	Recommended	---
Creatine Monohydrate	Recommended	---
Electrolyte Mix	Recommended	---
NAD+ Precursor (NMN/NR)	---	Recommended
Extra Virgin Olive Oil	---	Recommended
Green Tea (Matcha)	---	Recommended

Frequently Asked Questions

What is the difference between Peter Attia's and David Sinclair's protocols?

What do Peter Attia and David Sinclair both recommend?

Both experts recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.

Which protocol is better for beginners?

Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.