Peter Attia vs Mark Hyman
Compare Peter Attia's protocol (Physician & Longevity Researcher) with Mark Hyman's approach (Functional Medicine Physician & Author). Attia emphasizes medicine 3.0 and exercise, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate).
Peter Attia
Physician & Longevity Researcher
A Medicine 3.0 framework focused on the four horsemen of chronic disease, emphasizing zone 2 cardio, strength training, metabolic health, and early biomarker screening.
13 products in protocol
Mark Hyman
Functional Medicine Physician & Author
A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition.
15 products in protocol
Side-by-Side Comparison
| Category | Peter Attia | Mark Hyman |
|---|---|---|
| Title | Physician & Longevity Researcher | Functional Medicine Physician & Author |
| Focus Areas | medicine 3.0exercisemetabolic healthlongevitycardiovascular | functional medicinenutritiongut healthsupplementsanti aging |
| Total Products | 5 | 9 |
| Shared Products | 3 products in common | |
| Protocol | A Medicine 3.0 framework focused on the four horsemen of chronic disease, emphasizing zone 2 cardio, strength training, metabolic health, and early biomarker screening. | A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition. |
What They Agree On
Both Peter Attia and Mark Hyman include these 3 products in their protocols — a signal of strong evidence and broad expert consensus.
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Magnesium (Threonate/Glycinate)
supplements
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.
Only in Peter Attia's Protocol
Creatine Monohydrate
Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.
Electrolyte Mix
Balanced electrolyte mix containing sodium, potassium, and magnesium to support hydration and cellular function. Essential for maintaining energy levels, muscle function, and cognitive performance, especially during fasting or exercise. Sugar-free formulas are preferred in longevity protocols.
Only in Mark Hyman's Protocol
Probiotics (Multi-Strain)
Multi-strain probiotic supplement containing diverse beneficial bacteria to support gut microbiome health. A balanced gut microbiome is linked to improved digestion, immune function, and mental well-being. Look for formulas with clinically studied strains and high CFU counts.
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.
Vitamin C
High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.
Zinc (Picolinate)
Zinc picolinate supplement offering superior absorption compared to other zinc forms. Supports immune function, hormone production, and wound healing. Important for maintaining testosterone levels and thyroid health, particularly in those with dietary deficiencies.
Green Tea (Matcha)
High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.
Turmeric / Curcumin
Turmeric extract standardized for curcumin content, a potent anti-inflammatory compound. Supports joint health, reduces chronic inflammation, and may protect against age-related cognitive decline. Best absorbed when paired with piperine (black pepper extract) or in a liposomal formulation.
Product Comparison
| Product | Peter Attia | Mark Hyman |
|---|---|---|
| Omega-3 Fish Oil (High EPA) | Recommended | Recommended |
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Magnesium (Threonate/Glycinate) | Recommended | Recommended |
| Creatine Monohydrate | Recommended | --- |
| Electrolyte Mix | Recommended | --- |
| Probiotics (Multi-Strain) | --- | Recommended |
| Glutathione (Liposomal) | --- | Recommended |
| Vitamin C | --- | Recommended |
| Zinc (Picolinate) | --- | Recommended |
| Green Tea (Matcha) | --- | Recommended |
Frequently Asked Questions
What is the difference between Peter Attia's and Mark Hyman's protocols?
Compare Peter Attia's protocol (Physician & Longevity Researcher) with Mark Hyman's approach (Functional Medicine Physician & Author). Attia emphasizes medicine 3.0 and exercise, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate).
What do Peter Attia and Mark Hyman both recommend?
Both experts recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
supplements
Magnesium (Threonate/Glycinate)
supplements
Creatine Monohydrate
supplements
Electrolyte Mix
supplements
Probiotics (Multi-Strain)
supplements
Glutathione (Liposomal)
supplements
Vitamin C
supplements
Zinc (Picolinate)
supplements
Green Tea (Matcha)
foods
Turmeric / Curcumin
supplements
Links may earn us a commission at no extra cost to you.
More Comparisons
Get Protocol Comparisons in Your Inbox
New comparisons, product reviews, and the latest longevity research — weekly.