Mark Hyman vs David Sinclair
Compare Mark Hyman's protocol (Functional Medicine Physician & Author) with David Sinclair's approach (Harvard Genetics Professor & Aging Researcher). Hyman emphasizes functional medicine and nutrition, while Sinclair focuses on genetics and anti aging. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Green Tea (Matcha).
Mark Hyman
Functional Medicine Physician & Author
A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition.
15 products in protocol
David Sinclair
Harvard Genetics Professor & Aging Researcher
A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.
12 products in protocol
Side-by-Side Comparison
| Category | Mark Hyman | David Sinclair |
|---|---|---|
| Title | Functional Medicine Physician & Author | Harvard Genetics Professor & Aging Researcher |
| Focus Areas | functional medicinenutritiongut healthsupplementsanti aging | geneticsanti agingsirtuinssupplementsresearch |
| Total Products | 9 | 5 |
| Shared Products | 3 products in common | |
| Protocol | A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition. | A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions. |
What They Agree On
Both Mark Hyman and David Sinclair include these 3 products in their protocols — a signal of strong evidence and broad expert consensus.
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Green Tea (Matcha)
High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.
Green Tea (Matcha)
foods
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.
Only in Mark Hyman's Protocol
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Probiotics (Multi-Strain)
Multi-strain probiotic supplement containing diverse beneficial bacteria to support gut microbiome health. A balanced gut microbiome is linked to improved digestion, immune function, and mental well-being. Look for formulas with clinically studied strains and high CFU counts.
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.
Vitamin C
High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.
Zinc (Picolinate)
Zinc picolinate supplement offering superior absorption compared to other zinc forms. Supports immune function, hormone production, and wound healing. Important for maintaining testosterone levels and thyroid health, particularly in those with dietary deficiencies.
Turmeric / Curcumin
Turmeric extract standardized for curcumin content, a potent anti-inflammatory compound. Supports joint health, reduces chronic inflammation, and may protect against age-related cognitive decline. Best absorbed when paired with piperine (black pepper extract) or in a liposomal formulation.
Only in David Sinclair's Protocol
NAD+ Precursor (NMN/NR)
NAD+ precursor supplement in NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) form. Supports cellular energy production and DNA repair by boosting NAD+ levels, which naturally decline with age. A cornerstone supplement in many longevity-focused protocols.
Extra Virgin Olive Oil
Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.
Product Comparison
| Product | Mark Hyman | David Sinclair |
|---|---|---|
| Omega-3 Fish Oil (High EPA) | Recommended | Recommended |
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Green Tea (Matcha) | Recommended | Recommended |
| Magnesium (Threonate/Glycinate) | Recommended | --- |
| Probiotics (Multi-Strain) | Recommended | --- |
| Glutathione (Liposomal) | Recommended | --- |
| Vitamin C | Recommended | --- |
| Zinc (Picolinate) | Recommended | --- |
| NAD+ Precursor (NMN/NR) | --- | Recommended |
| Extra Virgin Olive Oil | --- | Recommended |
Frequently Asked Questions
What is the difference between Mark Hyman's and David Sinclair's protocols?
Compare Mark Hyman's protocol (Functional Medicine Physician & Author) with David Sinclair's approach (Harvard Genetics Professor & Aging Researcher). Hyman emphasizes functional medicine and nutrition, while Sinclair focuses on genetics and anti aging. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Green Tea (Matcha).
What do Mark Hyman and David Sinclair both recommend?
Both experts recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Green Tea (Matcha). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU), Green Tea (Matcha) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
supplements
Green Tea (Matcha)
foods
Magnesium (Threonate/Glycinate)
supplements
Probiotics (Multi-Strain)
supplements
Glutathione (Liposomal)
supplements
Vitamin C
supplements
Zinc (Picolinate)
supplements
Turmeric / Curcumin
supplements
NAD+ Precursor (NMN/NR)
supplements
Extra Virgin Olive Oil
foods
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