What supplements do both Dave Asprey and David Sinclair recommend?

Both Dave Asprey and David Sinclair recommend Extra Virgin Olive Oil, Vitamin D3 (5000 IU).

Which protocol is better: Dave Asprey or David Sinclair?

Both protocols have unique strengths. Dave Asprey's Biohacking Protocol focuses on biohacking, cognitive-performance, supplements, while David Sinclair's Lifespan Protocol emphasizes genetics, anti-aging, sirtuins. The best choice depends on your personal goals, budget, and lifestyle.

Dave Asprey vs David Sinclair

Compare Dave Asprey's protocol (Biohacker & Bulletproof Founder) with David Sinclair's approach (Harvard Genetics Professor & Aging Researcher). Asprey emphasizes biohacking and cognitive performance, while Sinclair focuses on genetics and anti aging. Both recommend Extra Virgin Olive Oil, Vitamin D3 (5000 IU).

Dave Asprey

Biohacker & Bulletproof Founder

A biohacking-focused protocol combining bulletproof coffee, intermittent fasting, targeted supplementation, and technology-assisted health optimization for cognitive performance and longevity.

14 products in protocol

David Sinclair

Harvard Genetics Professor & Aging Researcher

A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

12 products in protocol

Side-by-Side Comparison

Category	Dave Asprey	David Sinclair
Title	Biohacker & Bulletproof Founder	Harvard Genetics Professor & Aging Researcher
Focus Areas	biohackingcognitive performancesupplementsfasting	geneticsanti agingsirtuinssupplementsresearch
Total Products	4	5
Shared Products	2 products in common
Protocol	A biohacking-focused protocol combining bulletproof coffee, intermittent fasting, targeted supplementation, and technology-assisted health optimization for cognitive performance and longevity.	A genetics-informed anti-aging protocol centered on activating sirtuins and longevity genes through caloric restriction mimetics, NAD+ precursors, and targeted lifestyle interventions.

What They Agree On

Both Dave Asprey and David Sinclair include these 2 products in their protocols — a signal of strong evidence and broad expert consensus.

Extra Virgin Olive Oil

Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.

🌿

Extra Virgin Olive Oil

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Vitamin D3 (5000 IU)

High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.

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Vitamin D3 (5000 IU)

supplements

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Where They Differ

These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Only in Dave Asprey's Protocol

Collagen Peptides

Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.

Magnesium (Threonate/Glycinate)

Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.

Only in David Sinclair's Protocol

NAD+ Precursor (NMN/NR)

NAD+ precursor supplement in NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) form. Supports cellular energy production and DNA repair by boosting NAD+ levels, which naturally decline with age. A cornerstone supplement in many longevity-focused protocols.

Omega-3 Fish Oil (High EPA)

High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.

Green Tea (Matcha)

High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.

Product Comparison

Product	Dave Asprey	David Sinclair
Extra Virgin Olive Oil	Recommended	Recommended
Vitamin D3 (5000 IU)	Recommended	Recommended
Collagen Peptides	Recommended	---
Magnesium (Threonate/Glycinate)	Recommended	---
NAD+ Precursor (NMN/NR)	---	Recommended
Omega-3 Fish Oil (High EPA)	---	Recommended
Green Tea (Matcha)	---	Recommended

Frequently Asked Questions

What is the difference between Dave Asprey's and David Sinclair's protocols?

What do Dave Asprey and David Sinclair both recommend?

Both experts recommend Extra Virgin Olive Oil, Vitamin D3 (5000 IU). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.

Which protocol is better for beginners?

Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Extra Virgin Olive Oil, Vitamin D3 (5000 IU) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.