Ben Greenfield vs Valter Longo
Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Valter Longo's approach (Longevity Researcher & USC Professor). Greenfield emphasizes longevity and biohacking, while Longo focuses on fasting and longevity. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU).

Ben Greenfield
Exercise Physiologist & Biohacker
A comprehensive longevity protocol blending ancestral health practices with advanced biohacking — including targeted supplementation, cold and heat exposure, metabolic flexibility training, and a deep functional mushroom and adaptogen stack.
15 products in protocol

Valter Longo
Longevity Researcher & USC Professor
A research-backed fasting protocol centered on the fasting-mimicking diet (FMD), emphasizing periodic caloric restriction cycles to promote cellular regeneration and reduce biological age.
10 products in protocol
Side-by-Side Comparison
| Category | Ben Greenfield | Valter Longo |
|---|---|---|
| Title | Exercise Physiologist & Biohacker | Longevity Researcher & USC Professor |
| Focus Areas | longevitybiohackingsupplementsancestral healthfitnessadaptogens | fastinglongevityresearchdiet |
| Total Products | 15 | 3 |
| Shared Products | 2 products in common | |
| Protocol | A comprehensive longevity protocol blending ancestral health practices with advanced biohacking — including targeted supplementation, cold and heat exposure, metabolic flexibility training, and a deep functional mushroom and adaptogen stack. | A research-backed fasting protocol centered on the fasting-mimicking diet (FMD), emphasizing periodic caloric restriction cycles to promote cellular regeneration and reduce biological age. |
What They Agree On
Both Ben Greenfield and Valter Longo include these 2 products in their protocols — a signal of strong evidence and broad expert consensus.
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Only in Ben Greenfield's Protocol
Creatine Monohydrate
Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Electrolyte Mix
Balanced electrolyte mix containing sodium, potassium, and magnesium to support hydration and cellular function. Essential for maintaining energy levels, muscle function, and cognitive performance, especially during fasting or exercise. Sugar-free formulas are preferred in longevity protocols.
Collagen Peptides
Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.
Ashwagandha (KSM-66)
KSM-66 ashwagandha root extract, the most clinically studied form of this traditional adaptogenic herb. Supports healthy cortisol levels, reduces perceived stress, and may improve sleep quality and exercise recovery. Widely used in longevity protocols for its effects on hormonal balance and resilience to chronic stress.
Cordyceps Mushroom Extract
Concentrated cordyceps militaris mushroom extract standardized for cordycepin and adenosine content. Traditionally used to support endurance, oxygen utilization, and cellular energy production. Modern research suggests benefits for aerobic capacity and mitochondrial function.
Lion's Mane Mushroom Extract
Dual-extracted lion's mane mushroom (Hericium erinaceus) containing both hericenones and erinacines, compounds shown to stimulate nerve growth factor (NGF) production. Supports cognitive function, memory, and neuroplasticity. A staple in nootropic and longevity stacks for its unique neurotrophic properties.
Exogenous Ketones (BHB Salts)
Beta-hydroxybutyrate (BHB) salt supplement that rapidly elevates blood ketone levels without requiring extended fasting or strict carbohydrate restriction. Supports mental clarity, sustained energy, and may enhance endurance performance. Used as a bridging tool for metabolic flexibility in biohacking protocols.
Bovine Colostrum
Grass-fed bovine colostrum rich in immunoglobulins, lactoferrin, and growth factors. Supports gut barrier integrity, immune function, and recovery from intense exercise. Increasingly popular in longevity circles for its ability to reduce intestinal permeability and modulate inflammation.
Essential Amino Acids (EAAs)
Complete essential amino acid formula providing all nine EAAs in research-backed ratios. Supports muscle protein synthesis, recovery, and lean body composition with minimal caloric load. Preferred over BCAAs alone because the full EAA profile is required for complete protein turnover and tissue repair.
Molecular Hydrogen Tablets
Effervescent tablets that dissolve in water to produce molecular hydrogen (H2) gas. Molecular hydrogen acts as a selective antioxidant, neutralizing hydroxyl radicals without disrupting beneficial reactive oxygen species. Emerging research suggests benefits for exercise recovery, inflammation reduction, and mitochondrial health.
Quercetin
Quercetin is a plant flavonoid with potent antioxidant and anti-inflammatory properties. Supports immune function, cardiovascular health, and has been studied as a senolytic agent that helps clear damaged senescent cells. Often combined with vitamin C or bromelain to enhance absorption.
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.

Only in Valter Longo's Protocol
Extra Virgin Olive Oil
Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.
Product Comparison
| Product | Ben Greenfield | Valter Longo |
|---|---|---|
| Omega-3 Fish Oil (High EPA) | Recommended | Recommended |
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Creatine Monohydrate | Recommended | --- |
| Magnesium (Threonate/Glycinate) | Recommended | --- |
| Electrolyte Mix | Recommended | --- |
| Collagen Peptides | Recommended | --- |
| Ashwagandha (KSM-66) | Recommended | --- |
| Extra Virgin Olive Oil | --- | Recommended |
Frequently Asked Questions
What is the difference between Ben Greenfield's and Valter Longo's protocols?
Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Valter Longo's approach (Longevity Researcher & USC Professor). Greenfield emphasizes longevity and biohacking, while Longo focuses on fasting and longevity. Both recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU).
What do Ben Greenfield and Valter Longo both recommend?
Both experts recommend Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Vitamin D3 (5000 IU) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Omega-3 Fish Oil (High EPA)
supplements
Vitamin D3 (5000 IU)
supplements
Creatine Monohydrate
supplements
Magnesium (Threonate/Glycinate)
supplements
Electrolyte Mix
supplements
Collagen Peptides
supplements
Ashwagandha (KSM-66)
supplements
Cordyceps Mushroom Extract
supplements
Lion's Mane Mushroom Extract
supplements
Exogenous Ketones (BHB Salts)
supplements
Bovine Colostrum
supplements
Essential Amino Acids (EAAs)
supplements
Molecular Hydrogen Tablets
supplements
Quercetin
supplements
Glutathione (Liposomal)
supplements
Extra Virgin Olive Oil
foods
Links may earn us a commission at no extra cost to you.
More Comparisons
Get Protocol Comparisons in Your Inbox
New comparisons, product reviews, and the latest longevity research — weekly.