Siim Land vs Dave Asprey
Compare Siim Land's Metabolic Autophagy protocol with Dave Asprey's biohacking approach. Both are self-described biohackers who use fasting, ketosis, and supplementation to push the boundaries of human performance and longevity — but Land builds his system around activating autophagy through time-restricted eating, cold exposure, and sauna, while Asprey focuses on cognitive performance with Bulletproof Coffee, MCT oil, and technology-assisted optimization. Land goes deeper on cellular biology; Asprey goes wider on biohacking tools and devices.
Siim Land
Biohacker, Author & Longevity Researcher
An autophagy-centered longevity protocol combining time-restricted eating, ketogenic nutrition, targeted supplementation, and environmental stressors like cold exposure and sauna to activate the body's cellular recycling and repair mechanisms.
12 products in protocol
Dave Asprey
Biohacker & Bulletproof Founder
A biohacking-focused protocol combining bulletproof coffee, intermittent fasting, targeted supplementation, and technology-assisted health optimization for cognitive performance and longevity.
14 products in protocol
Side-by-Side Comparison
| Category | Siim Land | Dave Asprey |
|---|---|---|
| Title | Biohacker, Author & Longevity Researcher | Biohacker & Bulletproof Founder |
| Focus Areas | autophagyfastingketolongevitybiohackingsupplementssleep | biohackingcognitive performancesupplementsfasting |
| Total Products | 12 | 4 |
| Shared Products | 3 products in common | |
| Protocol | An autophagy-centered longevity protocol combining time-restricted eating, ketogenic nutrition, targeted supplementation, and environmental stressors like cold exposure and sauna to activate the body's cellular recycling and repair mechanisms. | A biohacking-focused protocol combining bulletproof coffee, intermittent fasting, targeted supplementation, and technology-assisted health optimization for cognitive performance and longevity. |
What They Agree On
Both Siim Land and Dave Asprey include these 3 products in their protocols — a signal of strong evidence and broad expert consensus.
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Magnesium (Threonate/Glycinate)
supplements
Collagen Peptides
Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.
Collagen Peptides
supplements
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.
Only in Siim Land's Protocol
Melatonin (Low Dose)
Low-dose melatonin supplement to support natural circadian rhythm and sleep onset. Research suggests doses of 0.3-1 mg are often more effective than higher amounts for improving sleep quality. Also studied for its antioxidant properties and potential anti-aging benefits.
Glycine
Glycine is the simplest amino acid and a key building block for collagen, glutathione, and creatine. Supplementing with glycine supports sleep quality, joint health, and detoxification. Research suggests 3-5 grams before bed can improve sleep onset and next-day cognitive performance.
Creatine Monohydrate
Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.
Vitamin C
High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.
Spermidine
Spermidine is a naturally occurring polyamine that declines with age and is a potent inducer of autophagy, the cellular recycling process linked to longevity. Found in foods like wheat germ, aged cheese, and natto, spermidine supplementation has been associated with improved cardiovascular health and cognitive function in clinical studies.
CoQ10 (Coenzyme Q10)
Coenzyme Q10 is a naturally occurring antioxidant that plays a critical role in mitochondrial energy production. CoQ10 levels decline with age, making supplementation increasingly relevant for supporting cardiovascular health, cellular energy, and overall vitality. The ubiquinol form offers superior bioavailability compared to ubiquinone.
Green Tea (Matcha)
High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.
Only in Dave Asprey's Protocol
Extra Virgin Olive Oil
Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.
Product Comparison
| Product | Siim Land | Dave Asprey |
|---|---|---|
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Magnesium (Threonate/Glycinate) | Recommended | Recommended |
| Collagen Peptides | Recommended | Recommended |
| Melatonin (Low Dose) | Recommended | --- |
| Glycine | Recommended | --- |
| Creatine Monohydrate | Recommended | --- |
| Omega-3 Fish Oil (High EPA) | Recommended | --- |
| Glutathione (Liposomal) | Recommended | --- |
| Extra Virgin Olive Oil | --- | Recommended |
Frequently Asked Questions
What is the difference between Siim Land's and Dave Asprey's protocols?
Compare Siim Land's Metabolic Autophagy protocol with Dave Asprey's biohacking approach. Both are self-described biohackers who use fasting, ketosis, and supplementation to push the boundaries of human performance and longevity — but Land builds his system around activating autophagy through time-restricted eating, cold exposure, and sauna, while Asprey focuses on cognitive performance with Bulletproof Coffee, MCT oil, and technology-assisted optimization. Land goes deeper on cellular biology; Asprey goes wider on biohacking tools and devices.
What do Siim Land and Dave Asprey both recommend?
Both experts recommend Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate), Collagen Peptides. These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Vitamin D3 (5000 IU), Magnesium (Threonate/Glycinate), Collagen Peptides — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Vitamin D3 (5000 IU)
supplements
Magnesium (Threonate/Glycinate)
supplements
Collagen Peptides
supplements
Melatonin (Low Dose)
supplements
Glycine
supplements
Creatine Monohydrate
supplements
Omega-3 Fish Oil (High EPA)
supplements
Glutathione (Liposomal)
supplements
Vitamin C
supplements
Spermidine
supplements
CoQ10 (Coenzyme Q10)
supplements
Green Tea (Matcha)
foods
Extra Virgin Olive Oil
foods
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