Siim Land vs Bryan Johnson
Compare Siim Land's Metabolic Autophagy protocol with Bryan Johnson's Blueprint. Both are committed anti-aging biohackers pursuing measurable biological age reversal — but they approach it from opposite directions. Land centers on activating autophagy through fasting, ketosis, and environmental stressors like cold and sauna, while Johnson runs a data-driven, algorithm-controlled system with hundreds of biomarkers and a team of physicians. Land's protocol is accessible and self-directed; Johnson's is expensive and clinician-managed.
Siim Land
Biohacker, Author & Longevity Researcher
An autophagy-centered longevity protocol combining time-restricted eating, ketogenic nutrition, targeted supplementation, and environmental stressors like cold exposure and sauna to activate the body's cellular recycling and repair mechanisms.
12 products in protocol
Bryan Johnson
Entrepreneur & Longevity Pioneer
A rigorous, data-driven longevity protocol designed to slow and reverse biological aging through precise nutrition, supplementation, exercise, and sleep optimization.
13 products in protocol
Side-by-Side Comparison
| Category | Siim Land | Bryan Johnson |
|---|---|---|
| Title | Biohacker, Author & Longevity Researcher | Entrepreneur & Longevity Pioneer |
| Focus Areas | autophagyfastingketolongevitybiohackingsupplementssleep | anti agingbiohackingnutritionsupplements |
| Total Products | 12 | 5 |
| Shared Products | 3 products in common | |
| Protocol | An autophagy-centered longevity protocol combining time-restricted eating, ketogenic nutrition, targeted supplementation, and environmental stressors like cold exposure and sauna to activate the body's cellular recycling and repair mechanisms. | A rigorous, data-driven longevity protocol designed to slow and reverse biological aging through precise nutrition, supplementation, exercise, and sleep optimization. |
What They Agree On
Both Siim Land and Bryan Johnson include these 3 products in their protocols — a signal of strong evidence and broad expert consensus.
Collagen Peptides
Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.
Collagen Peptides
supplements
Dark Chocolate (85%+ Cacao)
High-cacao dark chocolate rich in flavanols and antioxidants. Studies link regular consumption to improved cardiovascular health, lower blood pressure, and enhanced cognitive function.
Dark Chocolate (85%+ Cacao)
foods
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.
Only in Siim Land's Protocol
Melatonin (Low Dose)
Low-dose melatonin supplement to support natural circadian rhythm and sleep onset. Research suggests doses of 0.3-1 mg are often more effective than higher amounts for improving sleep quality. Also studied for its antioxidant properties and potential anti-aging benefits.
Glycine
Glycine is the simplest amino acid and a key building block for collagen, glutathione, and creatine. Supplementing with glycine supports sleep quality, joint health, and detoxification. Research suggests 3-5 grams before bed can improve sleep onset and next-day cognitive performance.
Creatine Monohydrate
Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.
Vitamin C
High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.
Spermidine
Spermidine is a naturally occurring polyamine that declines with age and is a potent inducer of autophagy, the cellular recycling process linked to longevity. Found in foods like wheat germ, aged cheese, and natto, spermidine supplementation has been associated with improved cardiovascular health and cognitive function in clinical studies.
CoQ10 (Coenzyme Q10)
Coenzyme Q10 is a naturally occurring antioxidant that plays a critical role in mitochondrial energy production. CoQ10 levels decline with age, making supplementation increasingly relevant for supporting cardiovascular health, cellular energy, and overall vitality. The ubiquinol form offers superior bioavailability compared to ubiquinone.
Green Tea (Matcha)
High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.
Only in Bryan Johnson's Protocol
Extra Virgin Olive Oil
Cold-pressed extra virgin olive oil, a cornerstone of Mediterranean and longevity diets. Rich in polyphenols and oleic acid.
Raw Macadamia Nuts
Raw, unsalted macadamia nuts prized for their high monounsaturated fat content and low omega-6 to omega-3 ratio. A favored fat source in longevity-focused diets for their anti-inflammatory profile.
Organic Blueberry Powder
Freeze-dried organic blueberry powder concentrated in anthocyanins and antioxidants. Supports cerebrovascular health, cognitive function, and cellular protection against oxidative stress.
Product Comparison
| Product | Siim Land | Bryan Johnson |
|---|---|---|
| Collagen Peptides | Recommended | Recommended |
| Dark Chocolate (85%+ Cacao) | Recommended | Recommended |
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Melatonin (Low Dose) | Recommended | --- |
| Glycine | Recommended | --- |
| Creatine Monohydrate | Recommended | --- |
| Magnesium (Threonate/Glycinate) | Recommended | --- |
| Omega-3 Fish Oil (High EPA) | Recommended | --- |
| Extra Virgin Olive Oil | --- | Recommended |
| Raw Macadamia Nuts | --- | Recommended |
| Organic Blueberry Powder | --- | Recommended |
Frequently Asked Questions
What is the difference between Siim Land's and Bryan Johnson's protocols?
Compare Siim Land's Metabolic Autophagy protocol with Bryan Johnson's Blueprint. Both are committed anti-aging biohackers pursuing measurable biological age reversal — but they approach it from opposite directions. Land centers on activating autophagy through fasting, ketosis, and environmental stressors like cold and sauna, while Johnson runs a data-driven, algorithm-controlled system with hundreds of biomarkers and a team of physicians. Land's protocol is accessible and self-directed; Johnson's is expensive and clinician-managed.
What do Siim Land and Bryan Johnson both recommend?
Both experts recommend Collagen Peptides, Dark Chocolate (85%+ Cacao), Vitamin D3 (5000 IU). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Collagen Peptides, Dark Chocolate (85%+ Cacao), Vitamin D3 (5000 IU) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Collagen Peptides
supplements
Dark Chocolate (85%+ Cacao)
foods
Vitamin D3 (5000 IU)
supplements
Melatonin (Low Dose)
supplements
Glycine
supplements
Creatine Monohydrate
supplements
Magnesium (Threonate/Glycinate)
supplements
Omega-3 Fish Oil (High EPA)
supplements
Glutathione (Liposomal)
supplements
Vitamin C
supplements
Spermidine
supplements
CoQ10 (Coenzyme Q10)
supplements
Green Tea (Matcha)
foods
Extra Virgin Olive Oil
foods
Raw Macadamia Nuts
foods
Organic Blueberry Powder
supplements
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