Ben Greenfield vs Rhonda Patrick
Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Rhonda Patrick's approach (Biomedical Scientist & Researcher). Greenfield emphasizes longevity and biohacking, while Patrick focuses on micronutrients and sauna. Both recommend Creatine Monohydrate, Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate) and 2 more.

Ben Greenfield
Exercise Physiologist & Biohacker
A comprehensive longevity protocol blending ancestral health practices with advanced biohacking — including targeted supplementation, cold and heat exposure, metabolic flexibility training, and a deep functional mushroom and adaptogen stack.
15 products in protocol

Rhonda Patrick
Biomedical Scientist & Researcher
A research-intensive protocol emphasizing micronutrient optimization, sauna therapy, sulforaphane supplementation, and omega-3 fatty acids for longevity and disease prevention — built on analysis of 140 FoundMyFitness episodes.
18 products in protocol
Side-by-Side Comparison
| Category | Ben Greenfield | Rhonda Patrick |
|---|---|---|
| Title | Exercise Physiologist & Biohacker | Biomedical Scientist & Researcher |
| Focus Areas | longevitybiohackingsupplementsancestral healthfitnessadaptogens | micronutrientssaunasupplementslongevityresearchsulforaphaneomega 3nrf2 |
| Total Products | 15 | 15 |
| Shared Products | 5 products in common | |
| Protocol | A comprehensive longevity protocol blending ancestral health practices with advanced biohacking — including targeted supplementation, cold and heat exposure, metabolic flexibility training, and a deep functional mushroom and adaptogen stack. | A research-intensive protocol emphasizing micronutrient optimization, sauna therapy, sulforaphane supplementation, and omega-3 fatty acids for longevity and disease prevention — built on analysis of 140 FoundMyFitness episodes. |
What They Agree On
Both Ben Greenfield and Rhonda Patrick include these 5 products in their protocols — a signal of strong evidence and broad expert consensus.
Creatine Monohydrate
Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.
Creatine Monohydrate
supplements
Omega-3 Fish Oil (High EPA)
High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.
Omega-3 Fish Oil (High EPA)
supplements
Magnesium (Threonate/Glycinate)
Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.
Magnesium (Threonate/Glycinate)
supplements
Vitamin D3 (5000 IU)
High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.
Vitamin D3 (5000 IU)
supplements
Glutathione (Liposomal)
Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.
Glutathione (Liposomal)
supplements
Where They Differ
These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Only in Ben Greenfield's Protocol
Electrolyte Mix
Balanced electrolyte mix containing sodium, potassium, and magnesium to support hydration and cellular function. Essential for maintaining energy levels, muscle function, and cognitive performance, especially during fasting or exercise. Sugar-free formulas are preferred in longevity protocols.
Collagen Peptides
Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.
Ashwagandha (KSM-66)
KSM-66 ashwagandha root extract, the most clinically studied form of this traditional adaptogenic herb. Supports healthy cortisol levels, reduces perceived stress, and may improve sleep quality and exercise recovery. Widely used in longevity protocols for its effects on hormonal balance and resilience to chronic stress.
Cordyceps Mushroom Extract
Concentrated cordyceps militaris mushroom extract standardized for cordycepin and adenosine content. Traditionally used to support endurance, oxygen utilization, and cellular energy production. Modern research suggests benefits for aerobic capacity and mitochondrial function.
Lion's Mane Mushroom Extract
Dual-extracted lion's mane mushroom (Hericium erinaceus) containing both hericenones and erinacines, compounds shown to stimulate nerve growth factor (NGF) production. Supports cognitive function, memory, and neuroplasticity. A staple in nootropic and longevity stacks for its unique neurotrophic properties.
Exogenous Ketones (BHB Salts)
Beta-hydroxybutyrate (BHB) salt supplement that rapidly elevates blood ketone levels without requiring extended fasting or strict carbohydrate restriction. Supports mental clarity, sustained energy, and may enhance endurance performance. Used as a bridging tool for metabolic flexibility in biohacking protocols.
Bovine Colostrum
Grass-fed bovine colostrum rich in immunoglobulins, lactoferrin, and growth factors. Supports gut barrier integrity, immune function, and recovery from intense exercise. Increasingly popular in longevity circles for its ability to reduce intestinal permeability and modulate inflammation.
Essential Amino Acids (EAAs)
Complete essential amino acid formula providing all nine EAAs in research-backed ratios. Supports muscle protein synthesis, recovery, and lean body composition with minimal caloric load. Preferred over BCAAs alone because the full EAA profile is required for complete protein turnover and tissue repair.
Molecular Hydrogen Tablets
Effervescent tablets that dissolve in water to produce molecular hydrogen (H2) gas. Molecular hydrogen acts as a selective antioxidant, neutralizing hydroxyl radicals without disrupting beneficial reactive oxygen species. Emerging research suggests benefits for exercise recovery, inflammation reduction, and mitochondrial health.
Quercetin
Quercetin is a plant flavonoid with potent antioxidant and anti-inflammatory properties. Supports immune function, cardiovascular health, and has been studied as a senolytic agent that helps clear damaged senescent cells. Often combined with vitamin C or bromelain to enhance absorption.

Only in Rhonda Patrick's Protocol
Sulforaphane / Broccoli Sprout Extract
Concentrated sulforaphane from broccoli sprout extract, a potent activator of the body's Nrf2 antioxidant pathway. Supports detoxification, reduces inflammation, and has been extensively studied for its cellular protective properties. Best absorbed when taken with a source of myrosinase.
Broccoli Sprouts
Fresh broccoli sprouts or sprouting seeds, the richest natural source of sulforaphane. Three-day-old sprouts contain 10-100 times more sulforaphane than mature broccoli. Easy to grow at home with a sprouting kit for a continuous supply of this powerful phytonutrient.
Vitamin C
High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.
NAD+ Precursor (NMN/NR)
NAD+ precursor supplement in NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) form. Supports cellular energy production and DNA repair by boosting NAD+ levels, which naturally decline with age. A cornerstone supplement in many longevity-focused protocols.
Melatonin (Low Dose)
Low-dose melatonin supplement to support natural circadian rhythm and sleep onset. Research suggests doses of 0.3-1 mg are often more effective than higher amounts for improving sleep quality. Also studied for its antioxidant properties and potential anti-aging benefits.
Zinc (Picolinate)
Zinc picolinate supplement offering superior absorption compared to other zinc forms. Supports immune function, hormone production, and wound healing. Important for maintaining testosterone levels and thyroid health, particularly in those with dietary deficiencies.
Probiotics (Multi-Strain)
Multi-strain probiotic supplement containing diverse beneficial bacteria to support gut microbiome health. A balanced gut microbiome is linked to improved digestion, immune function, and mental well-being. Look for formulas with clinically studied strains and high CFU counts.
Vitamin K2 (MK-7)
Vitamin K2 in the MK-7 form supports proper calcium metabolism, directing calcium into bones and teeth while preventing arterial calcification. Works synergistically with vitamin D3 to optimize bone mineral density and cardiovascular health. Essential for activating proteins involved in blood coagulation and vascular protection.
Folate (Methylfolate 5-MTHF)
Bioactive methylfolate (5-MTHF), the body-ready form of folate critical for DNA synthesis, repair, and methylation. Unlike synthetic folic acid, methylfolate bypasses the MTHFR enzyme conversion step, making it effective for individuals with common MTHFR gene variants. Supports homocysteine metabolism, neural tube development, and red blood cell formation.
Calcium (1000mg)
Calcium is essential for bone health, muscle function, and cardiovascular health throughout life. Adequate calcium intake helps prevent osteoporosis and supports proper nerve transmission and blood clotting. Longevity experts recommend calcium supplementation, especially for older adults, to maintain bone density and reduce fracture risk with aging.
Product Comparison
| Product | Ben Greenfield | Rhonda Patrick |
|---|---|---|
| Creatine Monohydrate | Recommended | Recommended |
| Omega-3 Fish Oil (High EPA) | Recommended | Recommended |
| Magnesium (Threonate/Glycinate) | Recommended | Recommended |
| Vitamin D3 (5000 IU) | Recommended | Recommended |
| Glutathione (Liposomal) | Recommended | Recommended |
| Electrolyte Mix | Recommended | --- |
| Collagen Peptides | Recommended | --- |
| Ashwagandha (KSM-66) | Recommended | --- |
| Cordyceps Mushroom Extract | Recommended | --- |
| Lion's Mane Mushroom Extract | Recommended | --- |
| Sulforaphane / Broccoli Sprout Extract | --- | Recommended |
| Broccoli Sprouts | --- | Recommended |
| Vitamin C | --- | Recommended |
| NAD+ Precursor (NMN/NR) | --- | Recommended |
| Melatonin (Low Dose) | --- | Recommended |
Frequently Asked Questions
What is the difference between Ben Greenfield's and Rhonda Patrick's protocols?
Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Rhonda Patrick's approach (Biomedical Scientist & Researcher). Greenfield emphasizes longevity and biohacking, while Patrick focuses on micronutrients and sauna. Both recommend Creatine Monohydrate, Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate) and 2 more.
What do Ben Greenfield and Rhonda Patrick both recommend?
Both experts recommend Creatine Monohydrate, Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU), Glutathione (Liposomal). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.
Which protocol is better for beginners?
Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Creatine Monohydrate, Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU), Glutathione (Liposomal) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.
All Products From Both Protocols
Creatine Monohydrate
supplements
Omega-3 Fish Oil (High EPA)
supplements
Magnesium (Threonate/Glycinate)
supplements
Vitamin D3 (5000 IU)
supplements
Glutathione (Liposomal)
supplements
Electrolyte Mix
supplements
Collagen Peptides
supplements
Ashwagandha (KSM-66)
supplements
Cordyceps Mushroom Extract
supplements
Lion's Mane Mushroom Extract
supplements
Exogenous Ketones (BHB Salts)
supplements
Bovine Colostrum
supplements
Essential Amino Acids (EAAs)
supplements
Molecular Hydrogen Tablets
supplements
Quercetin
supplements
Sulforaphane / Broccoli Sprout Extract
supplements
Broccoli Sprouts
foods
Vitamin C
supplements
NAD+ Precursor (NMN/NR)
supplements
Melatonin (Low Dose)
supplements
Zinc (Picolinate)
supplements
Probiotics (Multi-Strain)
supplements
Vitamin K2 (MK-7)
supplements
Folate (Methylfolate 5-MTHF)
supplements
Calcium (1000mg)
supplements
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