Ben Greenfield vs Mark Hyman

Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Mark Hyman's approach (Functional Medicine Physician & Author). Greenfield emphasizes longevity and biohacking, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU) and 1 more.

Side-by-Side Comparison

CategoryBen GreenfieldMark Hyman
TitleExercise Physiologist & BiohackerFunctional Medicine Physician & Author
Focus Areas
longevitybiohackingsupplementsancestral healthfitnessadaptogens
functional medicinenutritiongut healthsupplementsanti aging
Total Products159
Shared Products4 products in common
ProtocolA comprehensive longevity protocol blending ancestral health practices with advanced biohacking — including targeted supplementation, cold and heat exposure, metabolic flexibility training, and a deep functional mushroom and adaptogen stack.A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition.

What They Agree On

Both Ben Greenfield and Mark Hyman include these 4 products in their protocols — a signal of strong evidence and broad expert consensus.

Omega-3 Fish Oil (High EPA)

High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.

Omega-3 Fish Oil (High EPA)

supplements

Magnesium (Threonate/Glycinate)

Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.

Magnesium (Threonate/Glycinate)

supplements

Vitamin D3 (5000 IU)

High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.

Vitamin D3 (5000 IU)

supplements

Glutathione (Liposomal)

Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.

Glutathione (Liposomal)

supplements

Where They Differ

These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Ben Greenfield

Only in Ben Greenfield's Protocol

Creatine Monohydrate

Pure creatine monohydrate, one of the most well-researched supplements in sports science. Supports muscle strength, power output, and emerging research suggests cognitive benefits. Safe for long-term daily use at 3-5 grams per day.

Electrolyte Mix

Balanced electrolyte mix containing sodium, potassium, and magnesium to support hydration and cellular function. Essential for maintaining energy levels, muscle function, and cognitive performance, especially during fasting or exercise. Sugar-free formulas are preferred in longevity protocols.

Collagen Peptides

Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.

Ashwagandha (KSM-66)

KSM-66 ashwagandha root extract, the most clinically studied form of this traditional adaptogenic herb. Supports healthy cortisol levels, reduces perceived stress, and may improve sleep quality and exercise recovery. Widely used in longevity protocols for its effects on hormonal balance and resilience to chronic stress.

Cordyceps Mushroom Extract

Concentrated cordyceps militaris mushroom extract standardized for cordycepin and adenosine content. Traditionally used to support endurance, oxygen utilization, and cellular energy production. Modern research suggests benefits for aerobic capacity and mitochondrial function.

Lion's Mane Mushroom Extract

Dual-extracted lion's mane mushroom (Hericium erinaceus) containing both hericenones and erinacines, compounds shown to stimulate nerve growth factor (NGF) production. Supports cognitive function, memory, and neuroplasticity. A staple in nootropic and longevity stacks for its unique neurotrophic properties.

Exogenous Ketones (BHB Salts)

Beta-hydroxybutyrate (BHB) salt supplement that rapidly elevates blood ketone levels without requiring extended fasting or strict carbohydrate restriction. Supports mental clarity, sustained energy, and may enhance endurance performance. Used as a bridging tool for metabolic flexibility in biohacking protocols.

Bovine Colostrum

Grass-fed bovine colostrum rich in immunoglobulins, lactoferrin, and growth factors. Supports gut barrier integrity, immune function, and recovery from intense exercise. Increasingly popular in longevity circles for its ability to reduce intestinal permeability and modulate inflammation.

Essential Amino Acids (EAAs)

Complete essential amino acid formula providing all nine EAAs in research-backed ratios. Supports muscle protein synthesis, recovery, and lean body composition with minimal caloric load. Preferred over BCAAs alone because the full EAA profile is required for complete protein turnover and tissue repair.

Molecular Hydrogen Tablets

Effervescent tablets that dissolve in water to produce molecular hydrogen (H2) gas. Molecular hydrogen acts as a selective antioxidant, neutralizing hydroxyl radicals without disrupting beneficial reactive oxygen species. Emerging research suggests benefits for exercise recovery, inflammation reduction, and mitochondrial health.

Quercetin

Quercetin is a plant flavonoid with potent antioxidant and anti-inflammatory properties. Supports immune function, cardiovascular health, and has been studied as a senolytic agent that helps clear damaged senescent cells. Often combined with vitamin C or bromelain to enhance absorption.

Mark Hyman

Only in Mark Hyman's Protocol

Probiotics (Multi-Strain)

Multi-strain probiotic supplement containing diverse beneficial bacteria to support gut microbiome health. A balanced gut microbiome is linked to improved digestion, immune function, and mental well-being. Look for formulas with clinically studied strains and high CFU counts.

Vitamin C

High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.

Zinc (Picolinate)

Zinc picolinate supplement offering superior absorption compared to other zinc forms. Supports immune function, hormone production, and wound healing. Important for maintaining testosterone levels and thyroid health, particularly in those with dietary deficiencies.

Green Tea (Matcha)

High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.

Turmeric / Curcumin

Turmeric extract standardized for curcumin content, a potent anti-inflammatory compound. Supports joint health, reduces chronic inflammation, and may protect against age-related cognitive decline. Best absorbed when paired with piperine (black pepper extract) or in a liposomal formulation.

Product Comparison

ProductBen GreenfieldMark Hyman
Omega-3 Fish Oil (High EPA)RecommendedRecommended
Magnesium (Threonate/Glycinate)RecommendedRecommended
Vitamin D3 (5000 IU)RecommendedRecommended
Glutathione (Liposomal)RecommendedRecommended
Creatine MonohydrateRecommended---
Electrolyte MixRecommended---
Collagen PeptidesRecommended---
Ashwagandha (KSM-66)Recommended---
Cordyceps Mushroom ExtractRecommended---
Probiotics (Multi-Strain)---Recommended
Vitamin C---Recommended
Zinc (Picolinate)---Recommended
Green Tea (Matcha)---Recommended
Turmeric / Curcumin---Recommended

Frequently Asked Questions

What is the difference between Ben Greenfield's and Mark Hyman's protocols?

Compare Ben Greenfield's protocol (Exercise Physiologist & Biohacker) with Mark Hyman's approach (Functional Medicine Physician & Author). Greenfield emphasizes longevity and biohacking, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU) and 1 more.

What do Ben Greenfield and Mark Hyman both recommend?

Both experts recommend Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU), Glutathione (Liposomal). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.

Which protocol is better for beginners?

Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA), Magnesium (Threonate/Glycinate), Vitamin D3 (5000 IU), Glutathione (Liposomal) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.

All Products From Both Protocols

Omega-3 Fish Oil (High EPA)

supplements

Magnesium (Threonate/Glycinate)

supplements

Vitamin D3 (5000 IU)

supplements

Glutathione (Liposomal)

supplements

Creatine Monohydrate

supplements

Electrolyte Mix

supplements

Collagen Peptides

supplements

Ashwagandha (KSM-66)

supplements

Cordyceps Mushroom Extract

supplements

Lion's Mane Mushroom Extract

supplements

Exogenous Ketones (BHB Salts)

supplements

Bovine Colostrum

supplements

Essential Amino Acids (EAAs)

supplements

Molecular Hydrogen Tablets

supplements

Quercetin

supplements

Probiotics (Multi-Strain)

supplements

Vitamin C

supplements

Zinc (Picolinate)

supplements

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Green Tea (Matcha)

foods

Turmeric / Curcumin

supplements

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