Andrew Huberman vs Mark Hyman

Compare Andrew Huberman's protocol (Neuroscientist & Stanford Professor) with Mark Hyman's approach (Functional Medicine Physician & Author). Huberman emphasizes neuroscience and sleep, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA).

Side-by-Side Comparison

CategoryAndrew HubermanMark Hyman
TitleNeuroscientist & Stanford ProfessorFunctional Medicine Physician & Author
Focus Areas
neurosciencesleepsupplementsperformance
functional medicinenutritiongut healthsupplementsanti aging
Total Products39
Shared Products1 products in common
ProtocolA neuroscience-grounded protocol for optimizing sleep, focus, physical performance, and overall health through deliberate light exposure, targeted supplementation, and structured routines.A food-as-medicine protocol combining functional medicine principles with targeted supplementation, emphasizing gut health, blood sugar regulation, and anti-inflammatory nutrition.

What They Agree On

Both Andrew Huberman and Mark Hyman include these product in their protocols — a signal of strong evidence and broad expert consensus.

Omega-3 Fish Oil (High EPA)

High-potency omega-3 fish oil supplement with elevated EPA content. Supports cardiovascular health, reduces systemic inflammation, and promotes healthy brain function and mood regulation.

Omega-3 Fish Oil (High EPA)

supplements

Where They Differ

These products are unique to one protocol — reflecting each expert's distinct philosophy, research focus, and priorities.

Andrew Huberman

Only in Andrew Huberman's Protocol

Collagen Peptides

Hydrolyzed collagen peptides that support skin elasticity, joint health, and connective tissue repair. Easily dissolved in hot or cold liquids for convenient daily supplementation.

Organic Blueberry Powder

Freeze-dried organic blueberry powder concentrated in anthocyanins and antioxidants. Supports cerebrovascular health, cognitive function, and cellular protection against oxidative stress.

Mark Hyman

Only in Mark Hyman's Protocol

Vitamin D3 (5000 IU)

High-potency vitamin D3 supplement providing 5000 IU per serving to support optimal blood levels. Essential for immune function, bone health, and mood regulation. One of the most widely recommended supplements among longevity researchers due to widespread deficiency.

Magnesium (Threonate/Glycinate)

Highly bioavailable magnesium in threonate or glycinate form for superior absorption. Supports deep sleep quality, cognitive function, and nervous system relaxation. Magnesium threonate is particularly valued for its ability to cross the blood-brain barrier.

Probiotics (Multi-Strain)

Multi-strain probiotic supplement containing diverse beneficial bacteria to support gut microbiome health. A balanced gut microbiome is linked to improved digestion, immune function, and mental well-being. Look for formulas with clinically studied strains and high CFU counts.

Glutathione (Liposomal)

Liposomal glutathione supplement for enhanced absorption of the body's master antioxidant. Glutathione plays a critical role in detoxification, immune support, and protecting cells from oxidative stress. Liposomal delivery bypasses digestive breakdown for greater bioavailability.

Vitamin C

High-quality vitamin C supplement supporting immune function, collagen synthesis, and antioxidant defense. Essential for tissue repair and iron absorption. Liposomal forms offer enhanced bioavailability compared to standard ascorbic acid.

Zinc (Picolinate)

Zinc picolinate supplement offering superior absorption compared to other zinc forms. Supports immune function, hormone production, and wound healing. Important for maintaining testosterone levels and thyroid health, particularly in those with dietary deficiencies.

Green Tea (Matcha)

High-quality matcha green tea powder rich in EGCG catechins and L-theanine. Provides calm, sustained energy while delivering powerful antioxidant and anti-inflammatory benefits. Regular green tea consumption is associated with reduced cardiovascular disease risk and improved metabolic health in population studies.

Turmeric / Curcumin

Turmeric extract standardized for curcumin content, a potent anti-inflammatory compound. Supports joint health, reduces chronic inflammation, and may protect against age-related cognitive decline. Best absorbed when paired with piperine (black pepper extract) or in a liposomal formulation.

Product Comparison

ProductAndrew HubermanMark Hyman
Omega-3 Fish Oil (High EPA)RecommendedRecommended
Collagen PeptidesRecommended---
Organic Blueberry PowderRecommended---
Vitamin D3 (5000 IU)---Recommended
Magnesium (Threonate/Glycinate)---Recommended
Probiotics (Multi-Strain)---Recommended
Glutathione (Liposomal)---Recommended
Vitamin C---Recommended

Frequently Asked Questions

What is the difference between Andrew Huberman's and Mark Hyman's protocols?

Compare Andrew Huberman's protocol (Neuroscientist & Stanford Professor) with Mark Hyman's approach (Functional Medicine Physician & Author). Huberman emphasizes neuroscience and sleep, while Hyman focuses on functional medicine and nutrition. Both recommend Omega-3 Fish Oil (High EPA).

What do Andrew Huberman and Mark Hyman both recommend?

Both experts recommend Omega-3 Fish Oil (High EPA). These shared recommendations carry extra weight because they represent consensus across two independent, well-informed approaches to longevity.

Which protocol is better for beginners?

Both protocols can be adapted for beginners. Start with the fundamentals both experts agree on — Omega-3 Fish Oil (High EPA) — then gradually explore the unique elements of each protocol based on your specific health goals and budget.

All Products From Both Protocols

Omega-3 Fish Oil (High EPA)

supplements

Collagen Peptides

supplements

Organic Blueberry Powder

supplements

Vitamin D3 (5000 IU)

supplements

Magnesium (Threonate/Glycinate)

supplements

Probiotics (Multi-Strain)

supplements

Glutathione (Liposomal)

supplements

Vitamin C

supplements

Zinc (Picolinate)

supplements

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Green Tea (Matcha)

foods

Turmeric / Curcumin

supplements

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